Nutritional Frontiers CircuCORE, 120caps


Nutritional Frontiers CircuCORE provides the building blocks to support nitric oxide formation in order to enhance overall circulation including heart health and erectile dysfunction.* Nitric oxide is a soluble gas that is continually being made from arginine in endothelial cells. Endothelial cells comprise a layer of cells inside the lining of our blood vessels. The nitric oxide produced in endothelial cells mediates blood vessel dilation and reduces the stickiness of platelets, thereby helping to thin the blood. Nitric oxide is necessary for normal circulatory function– including erections. Impaired synthesis or increased degradation of nitric oxide are associated with hypertension, high cholesterol, and heart failure. Blood vessel function can be negatively affected by reduced nitric oxide, inflammation, and oxidative stress (also known as free radical damage)- and CircuCORE features a variety of ingredients that act as antioxidants, anti-inflammatories, and vasodilators.*

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Beet root powder presents some exciting possibilities for supporting cardiovascular health because of its high natural nitrate concentration. Beet root may potentially reduce triglycerides, regulate blood pressure and other cardiometabolic processes, and optimize blood flow throughout the body. Supplementing with red beet root was shown in a 2016 study to reduce blood pressure, cholesterol, and the inflammatory marker hsCRP. A 2018 study showed that dietary nitrate supplementation in the form of beet juice could help to improve blood flow during exercise in patients with congestive heart failure. An earlier small study investigated the benefits of daily intake of beet root juice and found that it increased plasma nitric oxide, reduced blood pressure, and lowered vascular resistance. These findings suggest that beet root juice may enhance oxygen delivery and reduce the workload of the heart.

Hawthorne herb has traditionally been utilized as a tonic to the heart and circulatory system. This plant contains a variety of flavonoids including oligomeric procyanidins (OPCs). Hawthorn is widely turned to in Europe for treating congestive heart failure (CHF). It may improve coronary artery blood flow, contractions of the heart muscle, exercise tolerance, and overall circulation.

Folate (as Quatrefolic® {equivalent to 100 mcg of [6S]-5- Methyltetrahydrofolic acid, glucosamine salt}) is a member of the B-vitamin family. Humans need to maintain an adequate dietary intake of folate during various stages of their lives to stay healthy. Folate performs multiple critical functions related to DNA synthesis and methylation, cell division, human growth and development, and nervous system function. Folate works together with vitamin B-12 to support normal production of important, mood-regulating neurotransmitters. Furthermore, methylated folate is essential for converting homocysteine to methionine, a process that protects cardiovascular health. Use of methylated folate prevents the potential negative effects of unconverted folic acid in the peripheral circulation.

L-Arginine is a semi-essential amino acid that enhances production of the vasodilator nitric oxide. Arginine is used clinically in conditions that are improved by vasodilation like heart failure, kidney failure, erectile dysfunction, and intermittent claudication. Trials show arginine can improve erectile dysfunction, sperm count, sperm quality.

Vitamin C (Ascorbic acid) exhibits a wide variety of benefits in the body. In terms of cardiovascular health, vitamin C is valuable for its antioxidant effects. Also, vitamin C aids in the production of collagen and therefore may help to strengthen blood vessel walls.*

L-Citrulline is an amino acid that the kidneys convert into L-arginine and nitric oxide. Therefore L-citrulline is included in formulations to boost nitric oxide production in the body. L-citrulline may help lower blood pressure in people whose blood pressure is trending high (pre-hypertension)* and it could also improve mild-to-moderate erectile dysfunction.

Activin® (grape seed extract) is a grape seed proanthocyanidin extract. Research studies have shown that ActiVin® possesses a wide range of antioxidant properties. It also demonstrates benefits as an anti-inflammatory agent. These benefits can be helpful in people with cardiovascular disease who may have higher free radical production.


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