Berberine is an alkaloid (type of plant constituent) derived from various wild plants with yellow roots, such as goldenseal, Oregon grape root, barberry, and goldthread. Studies in vitro, in animals, and in humans have demonstrated that berberine exhibits broad spectrum anti-fungal and anti-bacterial activity. Berberine has also been shown to be useful in the case of anti-fungal resistance. In other words, in the same way that overuse of antibiotics has resulted in antibiotic-resistant strains of bacteria, there are also antifungal-resistant cases of Candida infection.
Caprylic Aci is a medium-chain fatty acid commonly included in natural antifungal supplements. Some studies have shown that Caprylic Acid inhibits Candida growth. A 2012 Japanese study in mice demonstrated that Caprylic Acid was effective against both mycelial growth and yeast-form growth of Candida albicans in oral candidiasis. Caprylic Acid may have some antibacterial properties as well.
Olive Leaf Extract (Olea europaea) has been used by herbalists and in traditional folk medicines for many years to treat a variety of conditions. The olive tree is a small, evergreen tree native to the Mediterranean region. A 2013 Pakistani study verified that Olive Leaf Extract shows antifungal and antibacterial potential. Another 2013 study showed that olive extracts exhibited strong antimicrobial activity against various bacteria. Olive leaves not only possess antimicrobial characteristics, but also demonstrate antioxidant activity.
Grapefruit Seed Extract (Citrus x paradisi) was discovered by an American immunologist in 1980. It has been used to combat Candida and other infections. An in vitro study conducted in Poland showed that grapefruit seed extract exerted potent antifungal activity against various Candida yeast strains.
Garlic Bulb (Allium sativum) has been revered for thousands of years as a culinary and medicinal plant. Garlic is mentioned in the Bible, the Talmud, and by ancient physicians such as Hippocrates, Galen, Pliny the Elder, and Dioscorides. Garlic is often included in anti-microbial formulas. Modern research confirms its traditional use in fighting infections. Garlic also shows promise in preventing atherosclerosis, lowering cholesterol, and reducing excessive platelet adhesion.
Neem Leaf Powder Originated in Southeast Asia. Neem Leaf is used medicinally. Demonstrates anti-fungal activity. Plays a role in inhibiting growth of numerous microbes like viruses, bacteria, and pathogenic fungi.
Thyme Aerial Extract (Thymus vulgaris) is derived from the fragrant thyme plant, which is probably best known for its culinary use. Thyme also has many traditional medicinal uses: herbalists have used thyme for treating people with bronchitis, cough, upset stomach, whooping cough, and infections. Various studies have examined and verified the antimicrobial effects of thyme extract and thyme essential oil. Oregano Aerial Extract (Origanum vulgare) extracted from the leaf of oregano has been shown to have antifungal action, according to in vitro studies. In particular, one study showed benefits of oregano oil specifically against Candida albicans. Oregano is prized for both its culinary and medicinal applications, and is native to the Mediterranean region but is cultivated world-wide.